Skip to main content

Can I take 150 and Oestrogel pump-pack actuation together?

Drug interaction guide

Taking fluconazole alongside Oestrogel can increase the levels of oestrogen in your body. This may lead to an increased risk of side effects such as breast tenderness, nausea, headaches, or fluid retention (bloating).

Continue reading below

Why this happens

Fluconazole interferes with a specific enzyme in the liver (CYP3A4) that is responsible for breaking down oestrogen. Because the liver cannot clear the oestrogen as quickly as usual, the hormone builds up in your bloodstream.

You can usually take these together, but you should be mindful of any new or worsening side effects. If you notice significant breast pain, severe headaches, or unusual swelling, speak to your doctor. They may suggest a temporary adjustment or a different antifungal treatment.

Continue reading below

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
flu eligibility checker

Ask, share, connect.

Browse discussions, ask questions, and share experiences across hundreds of health topics.

symptom checker

Feeling unwell?

Assess your symptoms online for free

Sign up to the Patient newsletter

Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.

Please enter a valid email address

By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.