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Can I take 2.5mg and Mirtazapine together?

Drug interaction guide

Taking these two medicines together can make you feel very sleepy, dizzy, or unsteady on your feet. It may also affect your breathing, making it slower or shallower than usual.

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Why this happens

Both medicines act on the central nervous system (the brain) to cause sedation. When taken together, their effects add up, leading to much stronger drowsiness and a higher risk of coordination problems or breathing difficulties.

Use this combination with extreme caution. Do not drive, operate machinery, or perform tasks that require alertness until you know how this mix affects you. Avoid alcohol, as it will make these side effects much worse. If you feel excessively sleepy or have trouble breathing, contact your doctor immediately.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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