Can I take 4.5mg and Sertraline together?

Why this happens

Both sertraline and cannabis affect chemicals in the brain, including serotonin. When used together, they can have an 'additive' effect, meaning the side effects of both are strengthened. Furthermore, both substances are processed by the same enzymes in the liver; cannabis can slow down the breakdown of sertraline, leading to higher levels of the medicine in your bloodstream.

It is best to avoid using cannabis while taking sertraline. If you do choose to use both, you must monitor yourself closely for extreme drowsiness or changes in your mental state. You should not drive or operate machinery. In the UK, it is illegal to drive with any cannabis in your system, regardless of whether you feel impaired. If you experience a rapid heartbeat, high fever, or severe shivering, seek medical help immediately.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.