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Can I take 5/40mg and Lorazepam together?

Drug interaction guide

Taking these two medicines together can make you feel extremely sleepy, dizzy, and confused. It can also cause your breathing to become very slow or shallow, which can be life-threatening. You may also find it much harder to concentrate or coordinate your movements, increasing the risk of falls or accidents.

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Why this happens

Both oxycodone (the '5mg' part of your 5/40mg tablet) and lorazepam are 'central nervous system depressants'. This means they both slow down the activity in your brain and lungs. When taken together, their effects add up, making the sedation and breathing difficulties much stronger than if you took either medicine alone.

You should only take these two medicines together if they have been specifically prescribed by the same doctor who is aware you are taking both. If you must take both, use the lowest doses possible for the shortest amount of time. Seek emergency medical help immediately if you experience extreme sleepiness, fainting, or difficulty breathing. Do not drive or operate machinery while taking this combination.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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