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Can I take 50 and Adcal-d3 dissolve together?

Drug interaction guide

Taking Adcal-D3 (calcium and vitamin D) at the same time as sertraline (Zoloft) may slightly increase the risk of developing high calcium levels in your blood (hypercalcaemia). While this is not common, it can lead to symptoms like feeling sick, constipation, or feeling unusually tired. Additionally, sertraline can occasionally affect your bone density over long-term use, which is why your doctor may have prescribed Adcal-D3 to help support your bone health.

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Why this happens

Sertraline belongs to a group of medicines called SSRIs. Some studies suggest that SSRIs can interfere with how the body manages calcium and bone metabolism. When taken with calcium and vitamin D supplements, there is a theoretical risk that calcium levels could rise higher than intended, though this is usually only a concern if you have other health issues or take very high doses.

You can usually take these two medicines together, but it is important to follow the dose prescribed by your doctor. Do not take extra calcium supplements without checking first. If you start to feel unusually thirsty, need to urinate more often than usual, or feel very tired and sick, mention this to your doctor as they may want to check your calcium levels with a simple blood test.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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