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Can I take 50 and Lansopraxole together?

Drug interaction guide

Lansoprazole can significantly reduce the amount of 5-HTP that your body absorbs. This means the 5-HTP may not work as well as it should. Additionally, combining these can sometimes lead to an upset stomach or nausea.

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Why this happens

5-HTP requires a certain level of stomach acid to be broken down and absorbed properly. Lansoprazole works by reducing stomach acid, which changes the environment in your gut and prevents the 5-HTP from being taken up into your bloodstream effectively.

It is best to avoid taking these two at the same time. If you wish to take both, try to space them out by at least 2 to 4 hours. However, because 5-HTP can affect serotonin levels and lansoprazole changes stomach chemistry, you should speak to your doctor or pharmacist before using them together to ensure they are appropriate for you.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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