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Can I take 50 and Naproxen bp together?

Drug interaction guide

Taking these two medicines together significantly increases your risk of developing serious stomach problems, such as stomach ulcers, inflammation of the stomach lining (gastritis), or internal bleeding. It can also put extra strain on your kidneys.

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Why this happens

Both 50 (aspirin) and naproxen belong to the same family of medicines called NSAIDs (non-steroidal anti-inflammatory drugs). They work by blocking the same enzymes in the body. When you take both, you are essentially 'double-dosing' on this effect, which removes the protective lining of the stomach and reduces blood flow to the kidneys. Additionally, naproxen can interfere with aspirin's ability to protect your heart.

You should not take these two medicines together unless specifically instructed to do so by your doctor. If a doctor has prescribed both, they may also prescribe a 'stomach protector' medicine (like omeprazole). If you are taking these for pain, speak to a pharmacist or doctor about safer alternatives, such as paracetamol. Seek medical help immediately if you notice black, tarry stools or vomit that looks like coffee grounds.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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