Can I take 50 and Propranolol together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Taking 5-HTP and propranolol together can cause your blood pressure to drop too low or your heart rate to slow down too much. You may also experience increased side effects like drowsiness, dizziness, or feeling faint.
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Why this happens
Propranolol is a beta-blocker that lowers heart rate and blood pressure. 5-HTP increases serotonin levels, which can sometimes affect blood pressure regulation. Additionally, both substances can have a calming or sedative effect on the central nervous system, which can be additive when taken together.
What you should do
Back to contentsYou should speak to your doctor before combining these two. If you do take them together, monitor your blood pressure and heart rate regularly. Seek medical advice if you feel unusually dizzy, tired, or if you feel like you might faint.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Taking fluoxetine with Abilify (aripiprazole) can significantly increase the amount of Abilify in your bloodstream. This makes you much more likely to experience side effects such as extreme sleepiness, restlessness (feeling like you cannot sit still), uncontrollable body movements (tremors or twitching), and dizziness. There is also a small but serious risk of a heart rhythm problem called QT prolongation.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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