Can I take 50 and Sumatriptan together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
Taking 5-HTP and sumatriptan together can lead to a rare but very serious condition called 'serotonin syndrome'. This happens when there is too much of a chemical called serotonin in your brain and body. Symptoms can include shivering, sweating, a very fast heartbeat, muscle stiffness, twitching, and feeling very agitated or confused.
In this article:
Video picks for Drug interactions
Continue reading below
Why this happens
Both 5-HTP and sumatriptan increase the activity of serotonin. 5-HTP is a building block that the body uses to make more serotonin, while sumatriptan directly stimulates serotonin receptors to treat migraines. Using them at the same time can cause serotonin levels to rise to dangerous levels.
What you should do
Back to contentsYou should not take 5-HTP and sumatriptan together without speaking to your doctor first. If you are already taking both and feel unwell, seek medical help immediately. Your doctor may suggest an alternative treatment for your migraines or advise you to stop taking the 5-HTP supplement.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions
Treatment and medication
Can I take 150 and Zigduo together?
Taking aspirin (75mg to 150mg) with Xigduo (which contains dapagliflozin and metformin) can increase the risk of your blood sugar dropping too low (hypoglycaemia). It may also increase the risk of a rare but serious condition called lactic acidosis, where too much acid builds up in your blood.
Treatment and medication
Can I take Allerwel am and Calpol together?
There are no known harmful interactions between Allerwel AM and Calpol. It is generally safe to take these two medicines together as long as you follow the recommended doses for each.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.
Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.