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Can I take 500 and Ramipril together?

Drug interaction guide

Taking naproxen and ramipril together can increase the risk of kidney problems and may make your blood pressure medication less effective. It can also lead to high levels of potassium in your blood.

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Why this happens

Naproxen (an NSAID) can reduce the blood flow to the kidneys and cause the body to hold onto salt and water. This works against ramipril, which is trying to lower your blood pressure and protect your kidneys. Both drugs can also stop the body from getting rid of potassium properly.

You should speak to your doctor before taking these two medicines together. They may want to check your kidney function and blood pressure more frequently, or suggest an alternative painkiller like paracetamol. If you do take them together, ensure you stay well-hydrated and report any signs of swelling in your ankles or decreased urination to your doctor.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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