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Can I take 60 and Escitalopram together?

Drug interaction guide

Taking duloxetine (Cymbalta) and escitalopram (Lexapro) together significantly increases the risk of a rare but very serious condition called 'serotonin syndrome'. This occurs when there is too much of the chemical serotonin in your brain. Symptoms can include feeling very agitated, confused, or shaky, as well as sweating, a fast heartbeat, muscle twitching, or diarrhoea. In severe cases, it can be life-threatening.

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Why this happens

Both medicines work by increasing the levels of serotonin in the brain. Duloxetine is an SNRI (serotonin-norepinephrine reuptake inhibitor) and escitalopram is an SSRI (selective serotonin reuptake inhibitor). When used together, their effects add up, potentially pushing serotonin levels into a dangerous range.

You should not take these two medicines together unless specifically instructed and closely monitored by a specialist. If you are currently taking both, do not stop taking them suddenly, but contact your doctor immediately. Seek urgent medical help if you experience high fever, shivering, severe muscle stiffness, or seizures.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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