Can I take 60 and Sumatriptan together?
Drug interaction guide
Originally published 14 Mar 2026
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Taking these two medicines together can lead to a rare but very serious condition called serotonin syndrome. This happens when there is too much of a chemical called serotonin in your brain and body. Symptoms can include feeling very agitated, confused, or shaky, as well as sweating, a fast heartbeat, muscle twitching, or shivering. In severe cases, it can be life-threatening.
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Why this happens
Both duloxetine and sumatriptan increase the levels or activity of serotonin in the nervous system. When used at the same time, their effects can add up, causing serotonin levels to rise to a dangerous level.
What you should do
Back to contentsYou should speak to your doctor before taking these medicines together. If your doctor confirms you should take both, you must be very careful to watch for signs of serotonin syndrome. If you feel confused, agitated, have a very fast heartbeat, or experience muscle jerking, seek medical help immediately.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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