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Can I take 60 and Vitamin d3 together?

Drug interaction guide

There is no known interaction between Orlistat (Xenical) and Vitamin D3. However, Orlistat works by blocking the absorption of fat from your diet, and because Vitamin D is a 'fat-soluble' vitamin, Orlistat can prevent your body from absorbing it properly. This can lead to low Vitamin D levels over time.

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Why this happens

Orlistat attaches to the enzymes in your gut that break down fat. Since Vitamin D needs to be dissolved in fat to be absorbed into your bloodstream, blocking fat absorption also blocks the uptake of the vitamin.

To ensure you get enough Vitamin D, you should take your Vitamin D supplement at least 2 hours before or 2 hours after taking Orlistat (for example, at bedtime). It is also best to avoid or strictly limit alcohol while taking any medication to ensure your body processes the treatment effectively.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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