Can I take 7.5mg and Co-codamol together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
Taking zopiclone and co-codamol together can make you feel extremely sleepy, dizzy, and confused. It can also cause your breathing to become very slow or shallow, which can be dangerous.
In this article:
Video picks for Drug interactions
Continue reading below
Why this happens
Both zopiclone and the codeine in co-codamol are 'central nervous system depressants'. This means they both slow down brain activity and the signals that control breathing. When taken together, these effects add up and become much stronger.
What you should do
Back to contentsYou should only take these two medicines together if your doctor has specifically told you to do so and is aware you are taking both. If you do take them together, avoid alcohol, do not drive or operate machinery, and ensure someone is with you to monitor your breathing. Seek medical help immediately if you feel unusually drowsy or have difficulty breathing.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Atorvastatin and Magnesium together?
Taking magnesium antacids at the same time as atorvastatin can lower the amount of the statin medicine that your body absorbs. This might make your cholesterol treatment less effective.

Treatment and medication
Can I take Abilify and Fluoxetine together?
Taking fluoxetine with Abilify (aripiprazole) can significantly increase the amount of Abilify in your bloodstream. This makes you much more likely to experience side effects such as extreme sleepiness, restlessness (feeling like you cannot sit still), uncontrollable body movements (tremors or twitching), and dizziness. There is also a small but serious risk of a heart rhythm problem called QT prolongation.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.