Can I take Abacavir and Aspirin together?

Why this happens

Abacavir and aspirin are processed by different pathways in the body. Abacavir is primarily broken down by specific enzymes in the liver (alcohol dehydrogenase and glucuronyltransferase), while aspirin is broken down by esterases and then cleared by the kidneys. They do not interfere with each other's absorption or effectiveness.

You can take these medicines together as prescribed. However, always inform your doctor or pharmacist of all the medicines you are taking, including over-the-counter painkillers like aspirin, to ensure they are appropriate for your specific health needs.

Hypersensitivity Reaction (Genetic Risk)

You must be tested for the HLA-B*5701 gene before starting. If you develop a skin rash OR two or more of the following: fever, shortness of breath, sore throat, or extreme tiredness, stop taking it immediately and contact a doctor. Never restart abacavir if you have had a reaction.

Asthma

Do not take aspirin if you have a history of asthma, wheezing, or difficulty breathing triggered by aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs).

Children under 16 years old

Never give aspirin to children or teenagers under 16 unless specifically prescribed by a doctor, due to the risk of Reye’s syndrome, a rare but life-threatening condition.

Alcohol

Drinking alcohol while taking aspirin can increase the risk of irritation and bleeding in your stomach. It is best to limit alcohol intake or avoid it if you have a history of stomach issues.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.