Can I take Accetaminophen and Naproxen together?

Why this happens

These medicines have different 'mechanisms of action' (ways of working). Paracetamol works mainly in the central nervous system to reduce pain signals, while naproxen is a non-steroidal anti-inflammatory drug (NSAID) that reduces inflammation at the site of injury. Because they don't interfere with how the other is absorbed or broken down, they can be used together for 'additive' pain relief.

You can take these two medicines together, but you must ensure you do not exceed the maximum daily dose for either. Always follow the instructions on the packet or your doctor's advice. It is best to take naproxen with food to protect your stomach. If you have kidney problems or are dehydrated, speak to a pharmacist or doctor before combining these medicines. Avoid or strictly limit alcohol while taking these medicines, as both can be hard on your liver and stomach.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.