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Can I take Acetaminophen and Amlodipine together?

Drug interaction guide

There is no known direct interaction between paracetamol (acetaminophen) and amlodipine. However, you should be cautious with alcohol intake while taking these medicines.

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Why this happens

These two medicines are processed by the body in different ways and do not interfere with how the other works. Paracetamol is mainly processed by the liver, while amlodipine works on the blood vessels to lower blood pressure.

It is generally safe to take paracetamol while you are on amlodipine. However, it is best to avoid or strictly limit alcohol when taking paracetamol, as combining them increases the risk of liver damage. Additionally, if you are taking amlodipine for high blood pressure, be aware that some types of pain relief (like ibuprofen) can raise blood pressure, but paracetamol is usually the preferred choice as it does not typically affect blood pressure.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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