Can I take Acetaminophen and Trazodone together?

Why this happens

Both paracetamol and trazodone are metabolised (broken down) by the liver. While they use slightly different pathways, taking them together can put extra strain on the liver's processing capacity. There is also a theoretical risk that paracetamol could slightly slow down the breakdown of trazodone, leading to higher levels of the antidepressant in the system.

It is best to avoid or strictly limit alcohol when taking paracetamol, as combining them increases the risk of liver damage. If you are taking trazodone, alcohol will also significantly increase drowsiness and the risk of falls. You can take these two medicines together, but stick to the recommended dose of paracetamol (no more than four doses in 24 hours). If you feel unusually sleepy, dizzy, or notice any yellowing of your skin or eyes, speak to your doctor.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.