Can I take Acetaminophen and Vitamin c together?

Why this happens

Vitamin C and paracetamol are processed by the same pathway in the liver (called sulfation). When taken together in large amounts, they compete for this pathway. This slows down how quickly your body can get rid of paracetamol. Conversely, paracetamol uses up the body's stores of sulphate, which Vitamin C also needs, potentially leading to lower Vitamin C levels.

For most people taking standard doses, this is not a major concern. However, you should avoid taking very high doses of Vitamin C supplements (typically over 1000mg) if you are taking paracetamol regularly. It is best to avoid or strictly limit alcohol when taking paracetamol, as combining them increases the risk of liver damage. If you have kidney or liver problems, speak to your doctor before combining these.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.