Can I take Acetazolamide and Biquelle together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
Taking acetazolamide and Biquelle (quetiapine) together can increase the risk of certain side effects. Both medicines can cause drowsiness, dizziness, and a drop in blood pressure when you stand up (postural hypotension), which may lead to falls. Additionally, acetazolamide can affect the levels of salts (electrolytes) in your blood, which may increase the risk of a rare but serious heart rhythm problem associated with quetiapine.
In this article:
Video picks for Drug interactions
Continue reading below
Why this happens
Both drugs have 'central nervous system' depressant effects, meaning they slow down brain activity, leading to increased sleepiness. Acetazolamide is a diuretic (water tablet) that can lower potassium levels in the blood; low potassium increases the risk of quetiapine causing a heart rhythm disturbance known as QT prolongation.
What you should do
Back to contentsYou should use this combination with caution. It is important to have regular blood tests to monitor your salt levels (especially potassium and magnesium) as directed by your doctor. If you feel dizzy, confused, or notice a racing or fluttering heartbeat, seek medical advice immediately. Avoid or strictly limit alcohol, as it will make the drowsiness much worse.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Nustendi and Ramipril together?
Taking Nustendi and ramipril together can increase the risk of your kidneys not working as well as they should. It may also lead to high levels of potassium in your blood (hyperkalaemia).

Treatment and medication
Can I take Apixaban and Vitamin d together?
There is no known interaction between apixaban and vitamin D. It is generally considered safe to take these two together.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.