Can I take Acetazolamide and Folic acid together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Acetazolamide may increase the amount of folic acid your body gets rid of through your urine. This could lead to lower levels of folic acid in your blood over time.
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Why this happens
Acetazolamide is a diuretic (water tablet) that works by changing how your kidneys handle certain substances. It can increase the excretion of folate (folic acid) out of the body.
What you should do
Back to contentsYou can usually take these together, but you should inform your doctor if you are taking acetazolamide long-term. They may want to monitor your folic acid levels or suggest a supplement if your levels become low. If you are pregnant or planning a pregnancy, it is especially important to discuss this with your doctor as folic acid is vital for the baby's development.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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