Can I take Acetazolamide and Lamotrigine together?
Drug interaction guide
Originally published 14 Mar 2026
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Taking acetazolamide and lamotrigine together may increase the risk of developing metabolic acidosis (too much acid in the blood) and may increase the risk of kidney stones. There is also a possibility that acetazolamide could change the levels of lamotrigine in your blood, potentially making it less effective or increasing side effects like dizziness and blurred vision.
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Why this happens
Acetazolamide is a carbonic anhydrase inhibitor which can cause the blood to become more acidic. Lamotrigine can also slightly affect acid-base balance. When used together, this effect is worsened. Additionally, acetazolamide changes the acidity of urine, which can alter how the kidneys get rid of lamotrigine.
What you should do
Back to contentsYou should use this combination with caution. Speak to your doctor before taking these together. Your doctor may want to perform regular blood tests to check your acid levels and monitor your lamotrigine levels. Drink plenty of water to reduce the risk of kidney stones. If you notice unusual tiredness, shortness of breath, or a change in your seizure control, contact your doctor immediately.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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