Can I take Acetazolamide and Metformin together?

Why this happens

Metformin can naturally cause a small increase in lactic acid. Acetazolamide is a 'carbonic anhydrase inhibitor' which changes the acid balance in your blood and makes it harder for your body to clear acid. When used together, these two effects can combine, leading to a dangerous level of acid build-up. Acetazolamide may also affect how your kidneys clear metformin from your body.

You must speak to your doctor before taking these medicines together. If your doctor decides you need both, they will monitor your kidney function and blood acid levels closely. Seek urgent medical help if you experience extreme tiredness, rapid breathing, a slow or irregular heartbeat, or severe stomach upset while taking this combination.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.