Can I take Allopurinol and Felodipine together?
Drug interaction guide
Originally published 14 Mar 2026
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There is no known significant interaction between allopurinol and felodipine. It is generally considered safe to take these two medications together.
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Why this happens
Allopurinol (used for gout) and felodipine (a calcium channel blocker for blood pressure) are processed by different pathways in the body. Allopurinol is primarily cleared by the kidneys, while felodipine is broken down by specific enzymes in the liver (CYP3A4). Because they do not compete for the same 'processing machinery,' they do not interfere with each other's levels in the blood.
What you should do
Back to contentsYou can continue taking both medications as prescribed by your doctor. As with any blood pressure medication, you should monitor for side effects like dizziness or swollen ankles, but these are not increased by taking allopurinol.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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