Can I take Allopurinol and Metformin together?

Why this happens

Both allopurinol and metformin are cleared from the body by the kidneys. If the kidneys are not working at 100%, allopurinol can compete with metformin for removal, or the combination can put extra strain on kidney function. This can lead to a buildup of metformin, which increases the risk of lactic acidosis (a buildup of acid in the blood).

Most patients can take these medicines together safely, but it is important to have your kidney function checked regularly by your doctor (usually via a blood test). Seek immediate medical help if you experience signs of lactic acidosis, such as extreme tiredness, muscle pain, difficulty breathing, or feeling unusually cold.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.