Can I take Amitriptyline and Mirtazapine together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Taking these two medicines together can make you feel very sleepy, dizzy, and confused. It may also increase the risk of a rare but serious condition called serotonin syndrome, which can cause shivering, sweating, and a fast heartbeat. Additionally, both drugs can affect your heart rhythm and increase the risk of 'anticholinergic' side effects like a very dry mouth, blurred vision, and constipation.
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Why this happens
Both drugs work by increasing certain chemicals in the brain (serotonin and norepinephrine) and both have strong sedative effects. Because they both act on similar pathways, their effects add together (an additive effect), making side effects much more likely and intense.
What you should do
Back to contentsYou should only take these two medicines together if they have been specifically prescribed by a specialist who is monitoring you closely. If you feel extremely drowsy, faint, or notice a very fast or irregular heartbeat, seek medical advice immediately. Avoid driving or using machinery until you know how this combination affects you.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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