Can I take Amitriptyline and Omeprazole together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Taking omeprazole alongside amitriptyline can increase the levels of amitriptyline in your bloodstream. This may make you more likely to experience side effects such as extreme sleepiness, a dry mouth, blurred vision, constipation, or feeling dizzy. In some cases, it could also affect your heart rhythm.
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Why this happens
Amitriptyline is broken down (metabolised) in the liver by specific proteins called enzymes. Omeprazole can slow down the activity of these enzymes, which means the amitriptyline stays in your system longer and reaches higher levels than intended.
What you should do
Back to contentsYou can take these medicines together, but you should be aware of increased side effects. If you feel unusually drowsy, confused, or notice a fast or irregular heartbeat, contact your doctor. Your doctor may choose to lower your dose of amitriptyline if you need to take omeprazole for a long time.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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