Can I take Amitriptyline and Tadalafil together?

Why this happens

Both medications can lower blood pressure in different ways. Amitriptyline (a tricyclic antidepressant) can cause 'orthostatic hypotension' (a drop in blood pressure when standing), while tadalafil (used for erectile dysfunction) relaxes the blood vessels. When used together, these effects can add up, leading to a more significant drop in blood pressure.

Use this combination with caution. When moving from a lying or sitting position, stand up slowly to allow your body to adjust. If you feel dizzy or faint, sit or lie down immediately. If these symptoms are frequent or severe, speak to your doctor, as they may need to adjust your dosage. Avoid drinking alcohol, as this can make the dizziness worse.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.