Can I take Amitriptyline and Turmeric together?

Why this happens

Amitriptyline is broken down in the liver by specific enzymes (primarily CYP2D6 and CYP3A4). Curcumin, found in turmeric, can inhibit these enzymes. When these enzymes are blocked, the body cannot clear amitriptyline as quickly as usual, leading to higher levels of the drug in the system.

Use caution if combining these two. If you are taking amitriptyline, it is best to avoid high-dose turmeric or curcumin supplements without speaking to your doctor first. Using small amounts of turmeric in cooking is generally considered safe. If you do take both, watch out for increased side effects from your medication.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.