Can I take Amlodipene and Peppermint oil together?

Why this happens

Both amlodipine and peppermint oil act as 'calcium channel blockers' which relax the muscles in your blood vessels. When used together, they can have an additive effect, lowering blood pressure more than expected. Furthermore, peppermint oil can interfere with the liver enzymes (specifically CYP3A4) that break down amlodipine, leading to higher levels of the medicine in your bloodstream.

Use caution if combining these two. If you are taking enteric-coated peppermint oil capsules for IBS, try to take them at a different time of day than your amlodipine (at least 2 hours apart). Monitor your blood pressure regularly and watch for signs of low blood pressure, such as feeling dizzy or lightheaded, especially when standing up. If you feel unwell, speak to your GP or pharmacist.

Hiatus hernia or GORD (acid reflux)

Peppermint oil can relax the sphincter between the stomach and oesophagus, which may worsen heartburn or acid reflux symptoms.

Alcohol

While alcohol does not directly interact with amlodipine, both can lower your blood pressure. Drinking alcohol while taking amlodipine may make you feel dizzy, lightheaded, or sleepy. It is best to keep your alcohol intake within recommended limits and see how the medicine affects you first.

Meal timing

You should take peppermint oil capsules about 30 to 60 minutes before a meal. Do not take them immediately after eating, as this can cause the capsule to break down too early in the stomach, leading to heartburn.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.