Can I take Amlodipine and Ibuprofen together?

Why this happens

Amlodipine works by relaxing blood vessels to lower blood pressure. Ibuprofen causes the body to retain salt and water and blocks certain natural chemicals (prostaglandins) that help keep blood vessels open. These two effects work against each other.

If you only need a single dose of ibuprofen, it is usually fine, but avoid taking it regularly. If you need pain relief, paracetamol is a safer choice. If you must take both, monitor your blood pressure more frequently and speak to your GP if it starts to rise or if you notice swelling in your ankles.

Asthma

Do not take this medicine if you have asthma, as it can cause a life-threatening worsening of your breathing or a severe allergic reaction.

Stomach ulcers or bleeding

Avoid this medicine if you have ever had a stomach ulcer or gastrointestinal bleeding, as it significantly increases the risk of serious stomach perforation or bleeding.

High blood pressure or heart failure

Ibuprofen can raise your blood pressure and cause fluid retention, which may stop amlodipine from working effectively and worsen heart failure.

Grapefruit juice

Grapefruit juice can increase the amount of amlodipine in your body, which may cause your blood pressure to drop too low and increase the risk of side effects like headaches or swelling. It is best to avoid drinking large amounts of grapefruit juice while taking this medicine.

Alcohol

Drinking alcohol while taking ibuprofen can increase the risk of irritation to your stomach lining and may lead to stomach ulcers or bleeding. It is advisable to limit alcohol intake while taking this medication.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.