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Can I take Amlodipine and Isorbide together?

Drug interaction guide

Taking these two medicines together can cause your blood pressure to drop lower than usual. This might make you feel dizzy, lightheaded, or faint, especially when you stand up quickly. You may also experience a headache or a flushing sensation in your face.

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Why this happens

Both amlodipine and isosorbide (a nitrate) work by relaxing and widening your blood vessels to improve blood flow. Because they both do this in different ways, their effects add together, which can lead to a more significant drop in blood pressure than taking either medicine alone.

It is usually safe to take these together if your doctor has prescribed them, but you should be careful. When starting this combination or changing your dose, get up slowly from a sitting or lying position to avoid dizziness. If you feel very dizzy, sit or lie down immediately. Contact your doctor if you feel constantly lightheaded or if you faint.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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