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Can I take Amlodipine and Mirtazapine together?

Drug interaction guide

Taking amlodipine and mirtazapine together can cause your blood pressure to drop lower than intended. This may make you feel dizzy, lightheaded, or faint, especially when you stand up quickly from a sitting or lying position.

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Why this happens

Both medications have the side effect of lowering blood pressure. Amlodipine is designed to do this to treat hypertension, while mirtazapine can cause 'orthostatic hypotension' (a drop in blood pressure upon standing) as a secondary effect. When used together, these effects can add up.

You can take these medicines together, but you should be careful. Move slowly when changing positions (like getting out of bed) to avoid dizziness. Monitor your blood pressure regularly at home if possible. If you feel very dizzy, faint, or have a persistent headache, contact your doctor as they may need to adjust your doses.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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