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Can I take Amlodopine and Losartin together?

Drug interaction guide

Taking amlodipine and losartan together can cause your blood pressure to drop lower than if you took either medicine alone. While this is often the goal of treatment, it can sometimes lead to side effects like dizziness, lightheadedness, or fainting, especially when standing up quickly. There is also a small risk of affecting your kidney function or increasing potassium levels in your blood.

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Why this happens

Both medicines work to lower blood pressure but in different ways: amlodipine relaxes the blood vessels directly, while losartan blocks a hormone that causes blood vessels to tighten. Using them together has an 'additive' effect, meaning they combine their strengths to lower blood pressure more effectively.

What you should do

This is a very common and effective combination prescribed by doctors. You should monitor your blood pressure regularly at home. To avoid dizziness, try to get up slowly from a sitting or lying position. Ensure you attend your scheduled blood tests to check your kidney function and potassium levels. If you feel very dizzy or faint, contact your doctor.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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