Skip to main content

Can I take Amlodopine and Metformin together?

Drug interaction guide

Amlodipine may slightly reduce the blood-sugar-lowering effects of metformin. This means your blood sugar levels might stay a bit higher than usual when taking both medicines together.

Continue reading below

Why this happens

Amlodipine belongs to a group of medicines called calcium channel blockers. These can sometimes interfere with how the body releases insulin or how cells respond to it, which can slightly counteract the work metformin does to lower blood sugar.

What you should do

It is generally safe to take these together, but you should monitor your blood sugar levels more closely, especially when first starting amlodipine or if your dose changes. If you notice your blood sugar readings are consistently higher than your target range, speak to your doctor as they may need to adjust your metformin dose.

Continue reading below

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Continue reading below

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
flu eligibility checker

Ask, share, connect.

Browse discussions, ask questions, and share experiences across hundreds of health topics.

symptom checker

Feeling unwell?

Assess your symptoms online for free

Sign up to the Patient newsletter

Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.

Please enter a valid email address

By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.