Can I take Amlodopine and Metformin together?
Drug interaction guide
Originally published 25 Jan 2026
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Amlodipine may slightly reduce the blood-sugar-lowering effects of metformin. This means your blood sugar levels might stay a bit higher than usual when taking both medicines together.
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Why this happens
Amlodipine belongs to a group of medicines called calcium channel blockers. These can sometimes interfere with how the body releases insulin or how cells respond to it, which can slightly counteract the work metformin does to lower blood sugar.
What you should do
It is generally safe to take these together, but you should monitor your blood sugar levels more closely, especially when first starting amlodipine or if your dose changes. If you notice your blood sugar readings are consistently higher than your target range, speak to your doctor as they may need to adjust your metformin dose.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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