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Can I take Amlodopine and Quetiamine together?

Drug interaction guide

Taking these two medicines together can cause your blood pressure to drop lower than intended. This may make you feel dizzy, lightheaded, or faint, especially when you stand up quickly from a sitting or lying position. There is also a small risk that combining these drugs could affect your heart rhythm.

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Why this happens

Both amlodipine and quetiapine have the side effect of lowering blood pressure. Amlodipine is designed to do this, but quetiapine can also cause 'orthostatic hypotension' (a drop in blood pressure when standing). When used together, these effects add up. Additionally, quetiapine can occasionally affect the electrical activity of the heart (QT prolongation), and while amlodipine doesn't usually cause this, the combination requires caution.

What you should do

You can take these medicines together, but you should be careful. To prevent dizziness, try to stand up slowly. If you feel very dizzy, faint, or notice a fast or pounding heartbeat, contact your doctor. Your doctor may want to monitor your blood pressure more closely when you first start this combination or if your dose is changed.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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