Can I take Amlopidine and Glucosamine together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Glucosamine may slightly reduce the effectiveness of amlodipine, potentially leading to a small increase in blood pressure. There is also a very small risk that glucosamine could affect how your body processes the medication.
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Why this happens
Glucosamine is an amino sugar that may interfere with insulin sensitivity or blood sugar levels, which can indirectly influence blood pressure control. Some studies also suggest glucosamine might affect certain enzymes in the liver (CYP450) that break down amlodipine, though this effect is generally considered weak.
What you should do
Back to contentsIt is usually fine to take these together, but you should monitor your blood pressure more closely when starting or changing your dose of glucosamine. If you notice your blood pressure readings are consistently higher than usual, speak to your GP or pharmacist.
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Important precautions
Back to contentsShellfish allergy
Many glucosamine supplements are made from the shells of crustaceans. If you have a shellfish allergy, you must check the label for a 'shellfish-free' or vegan version to avoid a potentially severe allergic reaction.
Diabetes
Glucosamine is a type of sugar and may cause your blood glucose levels to rise. If you have diabetes, you should monitor your blood sugar more closely when starting or changing your dose of glucosamine.
Food and drink warnings
Back to contentsShellfish
Many glucosamine supplements are made from the shells of shellfish. If you have a shellfish allergy, you should check the label carefully or choose a vegan/shellfish-free version to avoid an allergic reaction.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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