Can I take Apixaban and Losartan together?

Why this happens

Apixaban is an anticoagulant (blood thinner) and losartan is an Angiotensin II Receptor Blocker (blood pressure medication). They are processed by different pathways in the body and do not interfere with how the other works.

What you should do

You can take these two medicines together as prescribed. Ensure you attend your regular blood pressure checks and blood tests for kidney function. If you notice any unusual bruising or bleeding (common with apixaban) or feel dizzy when standing up, inform your doctor.

Important precautions

Pregnancy

You must not take losartan if you are pregnant or planning to become pregnant. It can cause serious harm or death to an unborn baby, particularly if used in the second and third trimesters.

Emergency surgery or injury

You must carry an anticoagulant alert card at all times. Because apixaban thins your blood, you are at higher risk of serious bleeding if you have an accident or need emergency surgery.

Pain relief (NSAIDs)

Do not take ibuprofen, naproxen, or high-dose aspirin while taking apixaban unless specifically directed by a doctor. Taking these together significantly increases your risk of dangerous internal bleeding.

Food and drink warnings

Potassium-rich foods (e.g., bananas, spinach, salt substitutes)

Losartan can increase the levels of potassium in your blood. Consuming large amounts of potassium-rich foods or using salt substitutes containing potassium can lead to dangerously high potassium levels (hyperkalaemia).

Alcohol

While there is no direct interaction, alcohol can increase your risk of bleeding (relevant to Apixaban) and can lower your blood pressure further, potentially causing dizziness or fainting (relevant to Losartan). It is best to keep intake within recommended limits.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.