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Can I take Arcoxia and Cipralex together?

Drug interaction guide

Taking these two medicines together can increase your risk of internal bleeding, particularly in the stomach or gut. Both medicines can affect how your blood clots and can irritate the lining of the digestive tract.

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Why this happens

Arcoxia (etoricoxib) is a type of anti-inflammatory (NSAID) that can thin the blood and irritate the stomach. Cipralex (escitalopram) is an SSRI antidepressant that can also interfere with how platelets (the cells that help blood clot) work. When used together, their effects on bleeding are added together.

Speak to your doctor before taking these together. They may suggest a different painkiller or prescribe an extra medicine (like a proton pump inhibitor) to protect your stomach. Seek medical help immediately if you notice signs of bleeding, such as very dark or 'tarry' stools, coughing up blood, or vomit that looks like coffee grounds.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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