Can I take Ashwagandha and Escitalopram together?

Why this happens

Both substances affect brain chemistry. Escitalopram increases serotonin levels to treat depression/anxiety. Ashwagandha has calming effects on the central nervous system and may also slightly increase serotonin. When used together, their sedative effects can add up, and their combined impact on serotonin could potentially lead to an over-accumulation.

Use caution if combining these two. It is best to speak with your GP or pharmacist before starting ashwagandha while on escitalopram. If you do take both, monitor yourself for excessive sleepiness, dizziness, or signs of serotonin syndrome (such as shivering, sweating, a very fast heartbeat, or muscle twitching). If you experience these, stop the supplement and seek medical advice.

Serotonin Syndrome

Both medicines increase serotonin levels. Taking them together significantly increases the risk of serotonin syndrome, a potentially life-threatening condition. Seek immediate medical help if you experience agitation, rapid heartbeat, or muscle stiffness.

Hyperthyroidism (Overactive Thyroid)

Ashwagandha can increase thyroid hormone levels. You must not use it if you have an overactive thyroid, as it can worsen the condition or trigger a thyroid storm.

Bleeding Disorders

Escitalopram increases your risk of serious bleeding, especially in the stomach. This risk is much higher if you also take aspirin, ibuprofen (NSAIDs), or blood thinners like warfarin.

Alcohol

You should avoid or strictly limit alcohol while taking these medicines. Both escitalopram and ashwagandha can cause drowsiness and affect your coordination. Alcohol will significantly increase these sedative effects, making you feel more sleepy and increasing the risk of accidents.

Caffeine (Coffee, Tea, Energy Drinks)

Escitalopram can sometimes cause jitteriness or anxiety when you first start taking it. High amounts of caffeine can worsen these side effects. Monitor how you feel and consider reducing your caffeine intake if you feel restless or have trouble sleeping.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.