Can I take Aspirin 300 and Lanzoprole together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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Lansoprazole is actually beneficial when taken with aspirin. Aspirin can irritate the stomach lining and increase the risk of stomach ulcers or bleeding. Lansoprazole is a 'proton pump inhibitor' (PPI) that reduces stomach acid, which helps protect your stomach and lowers the risk of these side effects.
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Why this happens
Aspirin inhibits prostaglandins that protect the stomach lining, while lansoprazole reduces the production of gastric acid, thereby providing a protective effect against aspirin-induced gastric mucosal damage.
What you should do
It is safe and often recommended to take these together, especially if you are at risk of stomach issues. Take the lansoprazole at least 30 to 60 minutes before food (usually in the morning) for it to work best. If you notice any unusual stomach pain or black, tarry stools, contact your doctor.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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