Can I take Atorvastatin and Milk thistle together?

Why this happens

Milk thistle contains a compound called silymarin. Silymarin can interfere with certain proteins (transporters) and enzymes in the liver that are responsible for breaking down and removing atorvastatin from your body. When these processes are slowed down, the drug stays in your system longer and at higher concentrations.

What you should do

Use caution if combining these two. If you decide to take milk thistle, monitor yourself closely for any new or worsening muscle aches, pains, or weakness, as well as dark-coloured urine. It is best to inform your doctor or pharmacist before starting milk thistle so they can ensure your liver function is monitored appropriately.

Important precautions

Pregnancy

You must not take atorvastatin if you are pregnant or trying to conceive, as it can cause serious harm to an unborn baby. Use effective contraception while taking this medicine.

Muscle disorders

You must report any unexplained muscle pain, tenderness, or weakness to your doctor immediately, as this can rarely lead to serious kidney damage.

Liver disease

Atorvastatin should not be used if you have active liver disease or unexplained persistent elevations in liver enzymes.

Food and drink warnings

Grapefruit juice

Grapefruit juice contains compounds that can increase the level of atorvastatin in your blood. This can increase your risk of side effects, such as muscle pain or damage. Avoid drinking large amounts (more than 1.2 litres daily), though it is safest to avoid it altogether while taking this medicine.

Alcohol

Drinking large amounts of alcohol while taking atorvastatin can increase the risk of liver problems. It is recommended to keep your alcohol intake within the recommended limits (no more than 14 units per week).

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.