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Can I take Avastin and Naproxen together?

Drug interaction guide

Taking Avastin (bevacizumab) and naproxen together can significantly increase your risk of serious bleeding, particularly in the stomach or intestines. It may also increase the risk of developing a hole in the wall of the digestive tract (gastrointestinal perforation) and can put extra strain on your kidneys.

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Why this happens

Avastin works by stopping the growth of new blood vessels, which can make the lining of the stomach and intestines more fragile and slower to heal. Naproxen is an anti-inflammatory drug (NSAID) that can irritate the stomach lining and thin the blood slightly. When used together, these effects combine, making bleeding or damage to the digestive tract much more likely. Both drugs can also reduce blood flow to the kidneys.

You should avoid taking naproxen while you are being treated with Avastin unless your specialist doctor has specifically told you to do so. If you need pain relief, ask your doctor or pharmacist for a safer alternative, such as paracetamol. Seek medical help immediately if you notice signs of bleeding, such as black or tarry stools, coughing up blood, or severe stomach pain.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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