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Can I take Bisoprolol and Hydrochlorothiazide milpharm together?

Drug interaction guide

Taking these two medicines together can cause your blood pressure to drop lower than if you took either one alone. While this is often the intended effect to treat high blood pressure, it can sometimes make you feel dizzy, lightheaded, or faint, especially when standing up quickly. There is also a small risk that the combination could affect your blood sugar levels or certain salts (electrolytes) in your blood.

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Why this happens

Both medicines work to lower blood pressure but in different ways. Bisoprolol is a beta-blocker that slows the heart rate, while hydrochlorothiazide is a diuretic (water tablet) that helps the body get rid of excess salt and water. Because they both lower blood pressure, their effects add together.

This is a very common and effective combination, often found in a single 'combination' pill. You should monitor your blood pressure regularly. To avoid dizziness, try to get up slowly from a sitting or lying position. If you feel very dizzy, faint, or notice unusual muscle weakness or thirst, speak to your doctor. Your doctor may want to perform occasional blood tests to check your kidney function and salt levels.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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