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Can I take Bisoprolol and Sertraline together?

Drug interaction guide

Taking bisoprolol and sertraline together may occasionally cause your heart rate to slow down more than intended or lead to a slight drop in blood pressure when you stand up. While most people tolerate this combination well, it can sometimes lead to feeling dizzy, lightheaded, or unusually tired.

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Why this happens

Bisoprolol is a beta-blocker that slows the heart rate. Sertraline can sometimes interfere with the liver enzymes (specifically CYP2D6) that help clear bisoprolol from your body. This can lead to slightly higher levels of bisoprolol in your blood, increasing its effect on your heart rate and blood pressure.

You can usually take these medicines together, but you should monitor how you feel. If you experience dizziness, fainting, or a very slow pulse, speak to your GP. Do not stop taking either medication without medical advice. It is helpful to stand up slowly from a sitting or lying position to prevent lightheadedness.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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