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Can I take Bisoprolol and Spironolactone together?

Drug interaction guide

Taking bisoprolol and spironolactone together can cause your blood pressure to drop lower than usual. It can also lead to a build-up of potassium in your blood (hyperkalaemia).

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Why this happens

Both medicines work to lower blood pressure in different ways, so their effects add together. Additionally, both drugs can interfere with how your body gets rid of potassium, which can lead to high levels of this mineral in your system.

You can take these together, but your doctor should monitor you closely. You will likely need regular blood tests to check your kidney function and potassium levels. If you feel dizzy, lightheaded, or notice an irregular heartbeat, contact your doctor. Avoid using salt substitutes that contain potassium.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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