Can I take Candesartan and Lixiana together?

Why this happens

Candesartan is an ACE inhibitor-like drug used for blood pressure, and Lixiana is an anticoagulant (blood thinner). They do not interfere with each other's metabolism. However, candesartan can sometimes cause changes in kidney function, and Lixiana is partially cleared from the body by the kidneys.

What you should do

You can safely take these two medicines together. Ensure you attend your regular blood tests to monitor your kidney function, as your doctor may need to adjust your Lixiana dose if your kidney health changes. Seek medical advice if you notice unusual bruising or bleeding.

Important precautions

Pregnancy

You must not take candesartan if you are pregnant. It can cause serious harm or death to an unborn baby, especially if used during the second and third trimesters. Use effective contraception while taking it.

Active bleeding or high bleeding risk

Lixiana significantly increases your risk of bleeding. You must seek immediate medical attention if you have a serious fall, a head injury, or signs of internal bleeding such as black tarry stools or coughing up blood.

Food and drink warnings

Alcohol

Alcohol can increase the blood-pressure-lowering effect of candesartan, which may make you feel dizzy or light-headed. For Lixiana, heavy drinking can increase the risk of stomach bleeding. It is best to keep your alcohol intake within recommended limits.

Foods high in Vitamin K (e.g. leafy greens)

Unlike older blood thinners like warfarin, Lixiana is NOT affected by the amount of Vitamin K in your diet. You can continue to eat spinach, kale, and other leafy greens as normal.

Potassium-rich foods (e.g., bananas, spinach, salt substitutes)

Candesartan can increase the levels of potassium in your blood. Consuming large amounts of foods very high in potassium or using potassium-based salt substitutes (such as Lo-Salt) can lead to dangerously high potassium levels (hyperkalaemia). You should avoid using potassium-based salt substitutes unless advised otherwise by your doctor.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.