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Can I take Clobazam and Oxcarbazepine together?

Drug interaction guide

Taking clobazam and oxcarbazepine together can increase the levels of clobazam in your blood. This may make you feel more sleepy, dizzy, or unsteady than usual. It can also increase the risk of breathing difficulties or extreme tiredness.

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Why this happens

Oxcarbazepine can slow down the way your liver breaks down clobazam. This causes the clobazam to stay in your body longer and reach higher levels. Additionally, both medicines work by calming the brain, so taking them together can have an 'additive' effect on drowsiness.

You should use this combination with caution. Your doctor may need to adjust your doses or monitor you more closely when you start taking them together or change your dose. If you feel excessively sleepy, confused, or have trouble with your balance or breathing, contact your doctor immediately. Do not stop taking either medication without medical advice, as this could cause seizures to return.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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