Can I take Clopidogrel and Naproxen together?

Why this happens

Both medicines affect how your blood clots, but in different ways. Clopidogrel stops blood cells called platelets from sticking together. Naproxen is an anti-inflammatory (NSAID) that also reduces platelet activity and can irritate the lining of the stomach. When used together, their effects add up, making it much harder for your body to form clots and protect the stomach lining.

What you should do

You should only take these two medicines together if your doctor has specifically told you to do so. If you need pain relief while taking clopidogrel, paracetamol is usually a safer choice. If your doctor confirms you must take both, they may prescribe an extra medicine (like omeprazole or lansoprazole) to protect your stomach. Seek urgent medical help if you notice black, tarry stools, vomit that looks like coffee grounds, or severe stomach pain.

Important precautions

Surgery or dental work

You must tell any surgeon, anaesthetist, or dentist that you are taking clopidogrel. You may need to stop taking it 7 days before any planned procedure to prevent excessive bleeding.

Stomach ulcers or bleeding disorders

Do not take clopidogrel if you have an active stomach ulcer or any condition causing active bleeding. Seek urgent medical help if you notice signs of internal bleeding, such as black, tarry stools or vomiting blood.

Asthma

Do not take naproxen if you have ever had an asthma attack, wheezing, or a rash triggered by aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs).

Pregnancy (third trimester)

Do not take naproxen if you are more than 20 weeks pregnant, as it can cause serious heart or kidney problems in the unborn baby and lead to complications during delivery.

Food and drink warnings

Alcohol

Drinking alcohol while taking these medicines can increase the risk of bleeding in your stomach and intestines. It is best to limit your alcohol intake.

Food (General)

Naproxen should ideally be taken with or shortly after a meal or a snack. This helps to protect your stomach lining and reduces the risk of indigestion or stomach pain.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.