Can I take Clopodogrel and Isosorbate mononotrate together?
Drug interaction guide
Originally published 14 Mar 2026
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There is no direct harmful interaction between clopidogrel and isosorbide mononitrate. They are often prescribed together for heart conditions. However, both can contribute to a slight increase in the risk of bleeding or bruising, and isosorbide mononitrate can cause low blood pressure (dizziness), which may be more noticeable when starting new heart medications.
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Why this happens
Clopidogrel is an antiplatelet medicine that stops blood cells (platelets) from sticking together to prevent clots. Isosorbide mononitrate is a nitrate that widens blood vessels to improve blood flow. They work in different ways and do not interfere with how the body processes (metabolises) each other.
What you should do
Back to contentsYou can safely take these medicines together as prescribed by your doctor. Be aware that you may bruise more easily. If you feel dizzy or lightheaded, especially when standing up, move slowly and stay hydrated. Seek medical advice if you experience any unusual or heavy bleeding.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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